Cancer photoimmunotherapy
What is photoimmunotherapy?
Photoimmunotherapy is also called the "fifth treatment" following surgery, chemotherapy, radiation therapy, and immunotherapy, and is attracting attention as a new cancer treatment. Photoimmunotherapy is a treatment in which a drug that attaches only to cancer cells is administered, followed by irradiation with light (laser light, nearsighted ultraviolet light, ultrasound), causing the drug to react to the light and destroy the cancer cells. In addition to being able to pinpoint attack only cancer cells, it also has the effect of enhancing immunity against cancer.
副作用の少ないがん治療
ほぼ全身のがん種に対応
普段の生活を維持したまま治療可能
末期がん・再発・転移がんも治療対象
標準治療と併用できる
血管内治療（CTC治療）にも対応
Target cancer types
1
1. Photosensitive drugs administered intravenously
2
1. Photosensitive drugs administered intravenously
3
1. Photosensitive drugs administered intravenously
4
1. Photosensitive drugs administered intravenously
がん光免疫療法は体内のさまざまな場所にできたがん細胞にレーザー光を照射し直接的に腫瘍を破壊する攻撃と、その後全身に散らばったがん細胞を免疫細胞によって間接的に攻撃する、2つの作用をもつ治療法です。
Target cancer types
局所のがん細胞を破壊
Target cancer types
全身のがん細胞も破壊
Approaches tailored to the state of cancer are possible
At our clinic, we can select the wavelength of laser, near-infrared radiation, or ultrasound, or use them together, depending on the patient's condition and type of cancer. We also use different devices depending on the patient's condition, such as intradermal irradiation, intravascular irradiation, and external point or surface irradiation. By using near-infrared radiation and ultrasound, we can also treat cancers deep inside the body that are difficult for light to reach.
Approaches tailored to the state of cancer are possible
光免疫療法は、ほぼ全てのがん種（固形がん）に対応しております。
ステージⅠ～Ⅳ、再発がん、転移がん、がん予防についても治療のご提案をいたします。
※血液がんには対応しておりません。
Brain tumors
Head and neck cancer
Salivary gland cancer
Thyroid cancer
Lung cancer
Small cell lung cancer
Breast cancer
Mesothelioma
Pancreatic cancer
Liver cancer
Biliary tract cancer
Esophageal cancer
Stomach cancer
● GIST
Small intestine cancer
Colon cancer
Kidney cancer
Renal pelvis and ureter cancer
Bladder cancer
Prostate cancer
Cervical cancer
Ovarian cancer
Uterine sarcoma
Skin cancer
Melanoma
Sarcoma
Cancer of unknown primary origin
Approaches tailored to the state of cancer are possible
副作用の少ないがん治療
光免疫療法はがん細胞を選択的に破壊することで正常細胞への影響が少なく、治療後の副作用が極めて少ない治療法です。ご高齢の方や副作用が少ない治療をお探しの方からもお選びいただいている治療法です。年齢やがんのステージを問わず、光免疫療法を受けていただくことが可能です。
末期がん・再発・転移がんも治療対象
がん光免疫療法はレーザー光を照射した局所的な攻撃だけではありません。
レーザー光の照射によって破壊されたがん細胞から、がん細胞の抗体（がんの目印）が放出されます。放出された抗原を免疫細胞が取り込むことで、免疫細胞が体内に残っているがん細胞に対して攻撃が増強するという効果も見込めます。光免疫療法は治療をした部分のみのがん細胞のみならず、体の別の部分に存在するがん細胞を縮小・消失させることが期待できます。
ほぼ全身のがん種に対応
光免疫療法はほぼ全てのがん種（固形がん）に対応しております。
一般的に治療が困難とされる膵臓がんをはじめ、肺がん、大腸がん、乳がんなど多くのがん種に対して治療することができます。
標準治療と併用できる
光免疫療法は標準治療（手術、抗がん剤、放射線）の治療効果を妨げることはありません。
併用することで取りきれなかった目に見えないがん細胞の転移を防いだり、薬剤耐性を持ったがん細胞を攻撃したり、さまざまな相乗効果が期待できます。
手術
放射線
抗がん剤
光免疫療法
＋
普段の生活を維持したまま治療可能
光免疫療法は通院治療で受けられる治療です。
入院や休職する必要もなく、生活の質(QOL)を維持したまま、がんと闘うことができます。
Approaches tailored to the state of cancer are possible
当院では血管内治療(CTC治療)も行っています。 CTC治療は、がん細胞が血液中を流れる現象を対象とした治療法です。がんの転移・再発抑制に効果が期待できます。
血中循環がん細胞（CTC）、循環がん幹細胞（CSC）とは
がん細胞が一定の大きさに成長すると、栄養と酸素を求めて血管に侵入します。
これらのがん細胞は、血中循環がん細胞（CTC）と呼ばれ、さらに循環がん幹細胞（CSC）も放出されることがあります。
これらの細胞は、血管を通じて体内を移動し、新たながんの発生源となる可能性があります。
MLDS (Multi Laser Delivery System)
This is a laser device capable of low-power irradiation of less than 100 milliwatts. It can use six colors of light (ultraviolet, blue, green, yellow, red, near-infrared) and can be used to irradiate into the interstitium (inside the skin), blood vessels, and joints.
By irradiating the blood directly with laser light, circulating tumor cells (CTCs) present in blood vessels can also be destroyed.
Approaches tailored to the state of cancer are possible
当院では、患者様の状態やがん種に合わせて、レーザー・近赤外線・超音波の波長を選択、または併用することが可能です。照射方法も、皮膚内照射、血管内照射、外部から点的や面的な照射など、患者様の状態に合わせてデバイスを使い分けています。近赤外線や超音波を用いることで、光が届きにくい深部のがんに対しての治療もおこなっております。
Super Riser EX
The Super Laser is the first phototherapy device in Japan that can irradiate near-infrared light, the wavelength band with the deepest biological penetration of light, in a high-power spot pattern. It uses a high-precision LED as the light source, which allows the amount of light received in the body to be about five times that of conventional devices. In addition, by cutting off wavelengths of 1000 nm or more, it is possible to irradiate only wavelengths with excellent biological penetration.
※実際の治療では素肌の上から光を照射します
MLDS（マルチレーザーデリバリーシステム）
100ミリワット以下の低出力照射が可能なレーザー機器です。 MLDSは、静脈内・間質内・関節内・光線力学療法（PDT）として世界で初めて承認されたシステムです。 6色（紫外線、青、緑、黄、赤、近赤外線）の光線の使用が可能で、間質内（皮膚内）、血管内、関節内などに照射できます。
MLDS は、EU（CEマーキング）やFDAの承認医療機器として認められており世界30か国で使用されています。
Sonic Tizer
Ultrasound can reach deeper than light, so it can approach deep-seated cancers (lung cancer, prostate cancer, liver cancer, pancreatic cancer, etc.).
Photosensitizers used
At our clinic, we use indocyanine green or the more effective talaporfin as photosensitizing substances.
When a photosensitizer is exposed to a specific type of light, it absorbs the light and produces a type of reactive oxygen called singlet oxygen. Singlet oxygen destroys cancer cells, but normal cells are not destroyed by the action of an antioxidant enzyme called oxidase.
Treatment period and frequency
The treatment plan will vary depending on the patient's condition and symptoms, so we will decide after you have undergone an examination and tests.
Treatment period and frequency
The treatment plan will vary depending on the patient's condition and symptoms, so we will decide after you have undergone an examination and tests.
Treatment Overview
This treatment is an elective medical treatment.
Private medical treatment using unapproved drugs, etc.
The process of water injection
1. Counseling
A plastic surgeon will examine you and recommend treatment options.
2. Preparation for treatment
Please remove your makeup before the treatment.
If necessary, anesthesia will be administered to the treatment area.
3. Treatment
Beauty ingredients are injected using water injections.
The process of water injection
1. Counseling
A plastic surgeon will examine you and recommend treatment options.
2. Preparation for treatment
Please remove your makeup before the treatment.
If necessary, anesthesia will be administered to the treatment area.
3. Treatment
Beauty ingredients are injected using water injections.
The process of water injection
1. Counseling
A plastic surgeon will examine you and recommend treatment options.
2. Preparation for treatment
Please remove your makeup before the treatment.
If necessary, anesthesia will be administered to the treatment area.
3. Treatment
Beauty ingredients are injected using water injections.
The process of water injection
1. Counseling
A plastic surgeon will examine you and recommend treatment options.
2. Preparation for treatment
Please remove your makeup before the treatment.
If necessary, anesthesia will be administered to the treatment area.
3. Treatment
Beauty ingredients are injected using water injections.
The process of water injection
1. Counseling
A plastic surgeon will examine you and recommend treatment options.
2. Preparation for treatment
Please remove your makeup before the treatment.
If necessary, anesthesia will be administered to the treatment area.
3. Treatment
Beauty ingredients are injected using water injections.
Private medical treatment using unapproved drugs, etc.
Step 2: Damage only cancer cells while leaving normal cells intact
Even if the temperature of normal cells rises, they are quickly cooled to normal temperature because there are normal blood vessels around them and their temperature is around 37°C.
In contrast, cancer cells contain a lot of water and the surrounding blood vessels are weaker than normal blood vessels, meaning that they tend to heat up easily and are slow to cool down.
This difference in properties means that only cancer cells are damaged by heat.
Step 2: Damage only cancer cells while leaving normal cells intact
Even if the temperature of normal cells rises, they are quickly cooled to normal temperature because there are normal blood vessels around them and their temperature is around 37°C.
In contrast, cancer cells contain a lot of water and the surrounding blood vessels are weaker than normal blood vessels, meaning that they tend to heat up easily and are slow to cool down.
This difference in properties means that only cancer cells are damaged by heat.
Step 2: Damage only cancer cells while leaving normal cells intact
Even if the temperature of normal cells rises, they are quickly cooled to normal temperature because there are normal blood vessels around them and their temperature is around 37°C.
In contrast, cancer cells contain a lot of water and the surrounding blood vessels are weaker than normal blood vessels, meaning that they tend to heat up easily and are slow to cool down.
This difference in properties means that only cancer cells are damaged by heat.
Step 2: Damage only cancer cells while leaving normal cells intact
Even if the temperature of normal cells rises, they are quickly cooled to normal temperature because there are normal blood vessels around them and their temperature is around 37°C.
In contrast, cancer cells contain a lot of water and the surrounding blood vessels are weaker than normal blood vessels, meaning that they tend to heat up easily and are slow to cool down.
This difference in properties means that only cancer cells are damaged by heat.
Step 2: Damage only cancer cells while leaving normal cells intact
Even if the temperature of normal cells rises, they are quickly cooled to normal temperature because there are normal blood vessels around them and their temperature is around 37°C.
In contrast, cancer cells contain a lot of water and the surrounding blood vessels are weaker than normal blood vessels, meaning that they tend to heat up easily and are slow to cool down.
This difference in properties means that only cancer cells are damaged by heat.
Step 2: Damage only cancer cells while leaving normal cells intact
Even if the temperature of normal cells rises, they are quickly cooled to normal temperature because there are normal blood vessels around them and their temperature is around 37°C.
In contrast, cancer cells contain a lot of water and the surrounding blood vessels are weaker than normal blood vessels, meaning that they tend to heat up easily and are slow to cool down.
This difference in properties means that only cancer cells are damaged by heat.
Private medical treatment using unapproved drugs, etc.
●未承認医薬品等であることの明示、入手経路等の明示
本治療に用いるマイクロ波照射装置は、医薬品医療機器等法上の承認を得ていないものです。 日本国内では、未承認医療機器を、医師の責任において使用することができます。
●国内の承認医薬品等の有無
現在、本治療に用いるものと同一の性能を有する他の国内承認医薬品はありません。
●諸外国における安全性等に係る情報
本治療で使用するレーザーディバイス（MLDS）は、ヨーロッパ：CEマーキング、カナダ：Health Canada（カナダFDA）
アメリカ：US-FDA（外部レーザー治療、静脈内は適応外使用）等で医療機器ライセンスを取得しています。